Lung Cancer Cell Lines As Tools For Biomedical Discovery And Research

Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery.

Lung cancer cell lines as tools for biomedical discovery and research.

Research into new immunotherapies and new ways to use these treatments is ongoing. Blocking this pathway with pd 1 and pd l1 antibodies has stopped or slowed the growth of lung cancer for some patients. Lockwood et al lung cancer cell lines as tools for biomedical discovery and research j natl cancer inst 102 2010 pp. Lung cancer and normal cell lines atcc no.

Activity and safety of azd3759 in egfr mutant non small cell lung cancer with cns metastases bloom. Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. Non small cell lung cancer homo sapiens 59 yrs caucasian crl 2868 hcc827 lung epithelial adenocarcinoma homo sapiens.

But smoking is still responsible for most lung cancer deaths. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those. Gazdar af girard l lockwood ww lam wl minna jd 2010 lung cancer cell lines as tools for biomedical discovery and research.

A phase 1 open label dose escalation and dose expansion study. J natl cancer inst 102. Lee js ahn js et al. Lymph node 3b adenocarcinoma.

The pd 1 pathway may be very important in the immune system s ability to control cancer growth. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those for other common epithelial cancers. Research is continuing on.

The small cell lung cancer consortium was created to coordinate efforts and provide a network for small cell lung cancer investigators who focus on pre clinical studies of the disease. Lung cancer cell lines as tools for biomedical discovery and research.